Wodonga police said the b-double was travelling southbound on the Hume Highway when it veered onto the median strip about 2am. 

Sergeant Amanda Meagher said the driver over-corrected, causing the truck to turn onto its side and spill its load. 

The man, 49, suffered non-life threatening injuries and was airlifted to The Alfred hospital. 

The southbound lanes of the highway have since been closed, with traffic diverted through Barnawartha, onto the Chiltern-Barnawartha Road, to Chiltern and back onto the freeway. 

Emergency services remain on-scene, with delays expected. 

Sergeant Meagher said police were investigating the incident but fatigue appeared to have been a factor. 

Police are unable to say when the road might be reopened.