Myrtleford has grabbed a 34 per cent increase in percentage after positing one of its biggest wins in the past decade against Corowa-Rutherglen.
Missing their four best players, the winless Roos have never been more vulnerable and the Saints rammed on 28.11 (179) to 4.11 (35).
Ryley Sharp and Brad Murray, who turned 35 on Thursday, kicked five goals each, while interleague forward Frazer Dale booted four.
The home team had 13 goalkickers with Hugh Wales named best, while Lachlan Dale also played well.
The Roos will welcome star Riverina recruits James Lawton and Adam Cullen against Wangaratta.