City2City runners will this year be diverted along Church Street and through Junction Place as the South Street intersection remains closed for roadworks.
With the square growing in popularity ever year, organisers are considering whether to make the change permanent.
Co-founder Michelle Hudson said another first at Sunday’s event would be a $2000 cash draw at the finish line.
“It’s sponsored by The Printer Wizards and is for all open entries, it will be a random draw and a cheque presented at the end,” she said.
“There should be a lot happening with markets in Junction Place.
“Numbers are a little bit up on the same time last year, but we always have a major surge in registrations in the three days leading up to the event – 30 to 40 per cent come in then.”
The 7.5 kilometre Walk and Talk will return this year with participation expected to be split evenly with the 10.5 km and 7.5 km fun runs.
Proceeds from this year’s run will go to an Endobronchial ultrasound scope or E-Bus, a diagnostic tool commonly used for lung cancer, unfortunately in high demand at Albury Wodonga Health.
Ms Hudson encouraged people to sign up and get organised early.
“We really encourage people to collect their bibs before the day, to avoid congestion on Sunday,” she said.
“We’re really excited and we talk a lot about numbers, but at the end of the day it’s about everyone having a fantastic experience and celebrating our health service.”
To register go to: www.city2city.org.au