Fatal smash near Holbrook

A Melbourne man is dead and four others are injured in a single-car crash at Holbrook this afternoon.

Albury police Inspector Matt Tishler said at 5pm a car carrying five men ran off the north-bound lane of the Hume Freeway, 10km south of Holbrook.

He said the car collided with a tree and the front sear passenger was killed. The driver and three backseat passengers were taken to the Albury Base Hospital by ambulance.

The deceased is believed to be from Nunawading.

The cause of the crash is being investigated. 

One north-bound lane is closed and the second is closed intermittently as crime scene piece together clues. 

No diversions are in place and traffic is able to get through.