Dussin will attend his sister's wedding in Italy in early June, meaning he will miss the Saints 'big three' - Albury, Lavington and Wangaratta.

"I've put my hand up for that (interleague), I definitely thought about it (pulling out), but any opportunity to represent the league and help improve the status among the rest of the leagues is something I like doing and with 'Muz' (former Myrtleford coach Brad Murray) co-coaching, that made a big difference," Dussin said.

The 26-year-old was a co-vice-captain in last year's 76-point win over Western Region at Yarrawonga's JC Lowe Oval.

It elevated the O and M into AFL Victoria's third versus fourth playoff against Mornington Peninsula Nepean at Rosebud.

The winner will contest the prestigious one v two match next year.

Dussin's noble gesture undoubtedly helps the O and M's hopes of snapping a run of three straight losses to the beachside-centric league.

However, his absence reduces the chance of upsetting the Tigers, Panthers or Pies over that brutal three-week period.

Dussin has mainly played defence, although he's spent the last six quarters in the midfield.

"That just gave (coach) Jake (Sharp) the chance to try a couple of options down back while I'm away," he said.

"At this stage, Riley O'Shea (would take my position), he's a great leadup forward but probably some of the best footy I've seen him play has been down back.

"He reads the ball really well and he usually makes the right decision to spoil a mark, he's just a very solid backman."

The Saints currently lead the competition for the first time in years after six straight wins.

"For people who've been around for a long time, this bit of success has given them a bit of rejuvenation."