Just after 10am, a woman in her 50s driving a red Mazda was slowing down to turn left into the Australian Pumpkin Seed Company when a grey Mazda crashed into the back of her car.

Myrtleford Leading Senior Constable Jason Borbidge said she was not seriously injured but was shaken and was assessed by paramedics for a sore neck.

"The offending vehicle that has rear-ended the other car has extensive damage to its front," he said.

"Speaking to the male driver, it appears to be a concentration issue - speed or alcohol are not a factor.

"They've not driven far - only from Beechworth.

"He was travelling at about 80km/h when he has hit the other car - the woman said when she had last checked her speedometer she was travelling at about 40km/h."

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Leading Senior Constable Borbidge said the woman was driving alone in the red Mazda, but the male driver of the grey car, aged in his 30s, had a female passenger of the same age who was taken to hospital.

Ambulance Victoria spokesman John Mullen said crews were alerted to the crash at 10.10 am.

"Two patients were assessed, one requiring transport," he said.

"The woman has been placed into a neck brace in the case of possible spinal injuries.

"She was taken in a stable condition to Wangaratta Hospital."

Fire crews were called to the scene with reports of smoke coming out of the engine, but it was determined to be the radiator and not a fire.

Leading Senior Constable Borbidge said police were still considering possible charges.