Tallangatta and Mitta United will both head to Sandy Creek on Sunday with just one team set to be left standing.
It marks Mitta's first finals appearance since 2016 with the side ascending to fifth spot this season after a tenth place finish last year.
While the reigning premiers head into the clash with finals experience on their side, they possess a very different line-up to last season.
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"We know that if things don't go our way this weekend then there's no second chances," Tallangatta coach Erika O'Connell said.
"I think the big thing for us heading in is being focused for the whole game and not having lapses.
"If we can eliminate that we'll have a real shot at coming away with the win."
Tallangatta and Mitta will play the elimination final on Sunday at 2:50pm, while Rutherglen and Kiewa Sandy-Creek will meet in the qualifying final on Saturday.
Thurgoona are straight through to the semi-finals.