Star goal shooter Sarah Senini won't be at Lavington next season.
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The 2011 Toni Wilson Medallist and premiership player has featured in more than 300 games for the Panthers in her decorated A grade career.
Lavington is set to enter the 2020 Ovens and Murray netball campaign with a vastly different side.
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Long-time coach Tamara Mathews won't be at the helm with Catherine Wood taking over the top job in October.
Along with Senini, a host of experience has also departed with Skye Hillier, Kate Yensch, Rhiannon Dolahenty, Hailey Butler, Alison Meani and Kelly Simpson on the move.
Dolahenty will line up for Benalla, but the rest are yet to sign with a new club.
Lavington is set to take on Wodonga in the opening round of the season on April 4.
Wangaratta enters the year as back-to-back premiers after beating Corowa-Rutherglen in the decider.