The 2020 B2B walk follows the Murray to the Mountains rail trail from Beechworth to Bright over 75 kilometres from March 27 to 29.

Ms Cartledge, who in 2018 walked more than 700 kilometres from Beechworth to the north side of the Sydney Harbour Bridge to raise awareness and funds for suicide prevention, says this journey has only just begun.

This event, now in its third year, is close to home due to the level of community interest and support shown to the 2019 walk, she said.

"We have been so well looked after by the Beechworth, Myrtleford and Bright service clubs and a great team of volunteers that act as marshalls and provide meals and refreshments," said Beechworth-based Ms Cartledge, who lost her husband Sean to suicide in 2014.

"With the impact of the recent bushfires and the effects on mental health from drought, fire and the loss of homes, we are aware that it is as important as ever to walk and talk about the stuff that is going on in people's lives - without fear or judgement."

This year's walk will include a support bus so people who need a rest can be taken to the next drop-off point and people can also register to walk only the last five kilometres of day three.

"This is not a fun run and it is not a race," Ms Cartledge said.

"It is an opportunity to walk and talk or walk in companionable silence."

B2B fundraising in 2019 saw $7,000 donated to the Burrumbuttock Hay Runners' efforts to help drought-stricken farmers.