Myrtleford show organisers have made the "disappointing" decision to cancel the October event due to uncertainty around COVID-19 restrictions.
Show president Debbie Geddes said the society relies on volunteers and the financial backing of the town.
"We rely quite heavily on local businesses to donate money to us so we can offer prize money," she said.
"With the bushfires and the effect [on tourism]... plus the virus we didn't think it was fair to go to businesses to ask for money when they're doing it so tough."
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Mrs Geddes said even if come October 26 coronavirus gathering restrictions had lifted enough to allow the show to go ahead, a slew of new COVID-19 policies would need extra volunteers the society didn't have.
"We also weren't sure whether we'd get any rides," she said.
"Normally the sideshow alley people travel from one show to the next.
Wangaratta, Yarrawonga and Benalla shows have already cancelled, so Mrs Geddes was not sure the ride operators would attend.
"We're going to regroup and bring back a bigger and better show in 2021."