Wangaratta police are investigating after a cyclist was seriously injured in a car and bicycle crash at the intersection of Rowan Street and Baker Street about 3pm on Saturday.
Investigators were told the cyclist entered a roundabout the wrong way into the path of a car.
Police said the rider was wearing an unsecured helmet which came off during the impact.
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He was taken to hospital with serious injuries.
The driver of the car stopped and assisted police with their enquiries,
Police have appealed for anyone with information or dash cam footage to contact Crime Stoppers on 1800 333 000.