The northbound exit ramp from the Hume Freeway onto Greta Road at Wangaratta South is closed due to a truck rollover early this morning.
VicRoads is asking drivers to avoid the area with the ramp expected to be closed for several hours.
A Department of Transport statement said the closure is under police control.
IN OTHER NEWS:
"Drivers should allow extra time and exit the freeway earlier on to Glenrowan Road or at the Great Alpine Road," the statement said.
"The road will re-open when investigations are complete and it's safe to do so."
It isn't known if anyone was injured in the rollover.