Premier Daniel Andrews said in total 49 people have died.

He said a man in his 50s, a woman in her 70s, a man in his 80s, a man in his 90s and man in his 70s, had all died.

Of the new cases, Mr Andrews said roughly 370 were based in Melbourne or Mitchell Shire and 13 were in regional Victoria.

He said the remaining cases were still being investigated.

He said they were not seeing the level of growth in regional Victoria that would require further restrictions.

Yesterday, Mr Andrews said a record 484 new cases of COVID-19 had been detected.

New restrictions mandating the wearing of masks come into force in Melbourne and Mitchell shire today.

Watch Mr Andrews speak below.

Neither Albury Wodonga Health nor Murrumbidgee Local Health District have recorded new cases of COVID-19 so far this week.

IN OTHER NEWS:

Earlier today Victorian Treasurer Tim Pallas revealed Victoria's budget is expected to run a $7.5 billion deficit for the 2019/20 financial year.

"The coronavirus pandemic has really prompted a worldwide recession," Mr Pallas told reporters.

"That is, of course, as a result of both social distancing arrangements that impact upon business, the closure of national borders ... closure of state borders, as well as dwindling demand for Victoria's key export sectors."

- with Australia Associated Press