The motorcycle was travelling along Milos Boulevarde, near the intersection of De Kerilleau Drive, at about 5.55pm when it reportedly lost control.

Investigations by Wodonga Highway Patrol found that the motorcycle hit a gutter and a low brick fence, which catapulted the driver into a tree.

The force of the crash smashed the bricks in the fence.

The rider, a 48-year-old Wodonga man, was flown to The Alfred hospital in Melbourne.

As of Sunday afternoon, he remained in a critical but stable condition.

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Police, firefighters, SES volunteers and paramedics were all on the scene on Saturday evening, working to help stabilise the rider before he was placed in the air ambulance.

The cause of the crash has not been determined, but residents in the street have long been worried about speeding vehicles.

Nearby resident Lex Church, a former SES and CFA volunteer, told The Border Mail on Saturday that he heard a motorcycle going up the street earlier in the evening, then was told by neighbours that emergency services were at the scene of a crash.

"I hate seeing things like this," he said.

"It's a tragedy, yes, but people should stop and realise: please slow down."

He said it was common to hear cars up and down the street at night that are "definitely not abiding the speed limit".

"I have called out to people as they are driving past: 'you are nothing but idiots.' We have reported it and no one's done nothing about it," Mr Church said.

"Day and night, they just go up and down, they just completely ignore the speed limits.

"It's about time the police put a speed camera in this area and get these bastards."

He welcomed the suggestion of installing speed humps for the street or "anything to slow these idiots down".

Police have said the investigation is ongoing and asked anyone who witnessed the motorcycle crash, or who has dash-cam footage, to contact Crime Stoppers on 1800 333 000 or make a confidential report at crimestoppersvic.com.au.