Since the pair first opened the cafe in 2007, they've had six different locations across the border, most recently operating out of Birallee Shopping Centre.

"It's been a bit of an institution over all those years, so it will be a bit sad, we'll miss all our customers," Mr McNamara said.

Mr McNamara said the national COVID-19 lockdown followed by the Victorian specific restrictions had been hard on the business, but weren't the main reason behind the closure.

"Trade was way down, then people started to get used to what was going on and trade picked up a bit, but obviously it's still down on this time last year," he said.

"But mainly it's just health reasons, that's the major reason [behind the closure]."

Mr McNamara said Rox had been diagnosed with breast cancer which caused the pair to reconsider their priorities.

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"She's been through treatment, chemo, radiation, at the moment there's no evidence of cancer," he said.

"The type of cancer she's got, they never say 'it won't come back' so that's one of the reasons we want to back off a bit."

Mr McNamara said the centre was also moving in a different direction so they decided now would be the perfect time to part ways.

They are yet to decide what the future will hold, but they are looking forward to some family time before exploring their next venture.

"We're looking to have just a break at the moment, but there might be something in the wind," he said.

Mr McNamara thanked customers for their support and said the cafe's last day would be Thursday.