The Bureau of Meteorology have forecast a heatwave will hit the North East and Southern Riverina across Thursday, Friday, Saturday and Sunday.

Murrumbidgee Local Health District, which spans the Southern Riverina into Albury, has urged residents to take the risk of heat-related illnesses seriously.

Director Public Health Tracey Oakman said heat-related illness can affect anyone but adults over 75, young children, people who live alone and people with chronic medical conditions are particularly vulnerable.

"Every year hot weather and heat waves cause illness, hospitalisations and sometimes even deaths," she said.

"Heat puts a lot of strain on the body and can cause dehydration, heat exhaustion and heat stroke. It can also make underlying health conditions worse."

Mrs Oakman said drinking water and avoiding alcohol, hot or sugary drinks can help minimise the risk of heat-related illnesses.

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As can minimising physical activity and staying indoors as much as possible.

A high of 41 degrees Celsius is expected in Yarrawonga and Henty on Saturday, while the bureau predicts the temperature could reach 39 degrees in Wangaratta and 37 degrees in Albury-Wodonga.

The border is in for a couple of warm nights with minimum temperatures of 19 and 20 degrees expected in Albury-Wodonga on Saturday and Sunday.

There is a slight chance of a thunderstorm Saturday evening and maximum temperatures of mid to high 30s are expected across the North East and Southern Riverina through the week into the weekend.

The mean maximum temperature for November in Albury is 26.2 degrees, according to 27 years of temperature data.

Despite being hotter than usual for November, it's unlikely Saturday's temperatures will break records. The highest November temperature in Albury was recorded on November 20, 2019, when the mercury hit 40.9 degrees.

Yarrawonga's hottest November temperature, 42.4 degrees, was recorded on November 21 last year.