It's the first time a regional school has hosted a NAB League fixture with Western Jets to make the trip north for the clash.

The opportunity to host a match at the school has been several years in the making, with former Cathedral College principal Adrian Farrer, Ian Collins, new principal Nick Jones and Briana Cossar, who was the Murray Bushrangers girls talent coordinator in recent seasons, all instrumental in the process.

Assistant coach Mario de Santa-ana said the group trained strongly this week after a 10-day break before last weekend's game due to Victoria's snap lockdown.

"Historically we've played at the major venues around the region, but this is the first time a regional school has hosted a NAB League game, boys or girls," he said.

"I think the girls were a bit worried restrictions were going to kick in like they did last season, but they were really on their game at training and the intensity was good."

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Seven changes have been made to the side, with a host of players unavailable due to GWS academy commitments, while Sophie Locke and Kate Adams have earned VFLW debuts with Port Melbourne.

Cathedral College student Sam Peppler, Sophie Boyle, Lily Kozuharoff, Isabella Symes, Natasha Wilson and Matilda Lyons are among the inclusions.

"We're not really sure what to expect, but we're pretty enthusiastic about the group we've got on the ground, de Santa-ana said.

"Matilda Lyons is from Alpine Lions and makes her debut at 14 and Tash Wilson plays for Thurgoona and is 14 as well."

First bounce is at 12.15pm.

The round four team is: B: Chloe Locke, Mindy Quade, Cody Power; HB: Tayissa Gray, Molly Kennedy, Grace Hay; C: Aurora Smith, Madison Gray, Taylah Power; HF: Kristy Whitehead, Sophia McCarthy, Kasey Boschetti; F: Sam Peppler, Kaylea Kobzan, Jesse Elias; R: Emily Williams, Keeley Skepper, Sarah Lange-Richards; INT: Sophie Boyle, Lily Kozuharoff, Ashleigh Pilmott, Natasha Wilson, Issy Symes, Matilda Lyons; EMG: Bella Fielder, Yasmin Budic

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