Flexible wire rope barriers will be installed along the Olympic Highway between Albury, Wagga and Cowra as part of a $2.5 million safety upgrade.
More than 260 crashes occurred on the highway in the five-years to June 2018.
Installation of the flexible wire safety barrier will start on April 6 and continue through to at least late June.
Lane closures and a 40km/h speed limit will be in place during work hours.
Residents should expect delays and drive to the conditions.
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Drivers are asked to follow the directions of signs and traffic controls.
Member for Cootamundra Steph Cook said 600 kilometres of rumble strips had already been installed on the highway as part of the Saving Lives on Country Roads initiative.
Member for Albury Justin Clancy said the barriers were being rolled out as part of the government's commitment to stronger and safer regions.
"We will have about 30 people working at several locations between Wagga Wagga, Bethungra, Cowra and Albury installing this life saving treatment which can reduce the severity of crashes by 95 per cent," Mr Clancy said.
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