Ms Holland announced her resignation late last week after five years in the role.

Seven days earlier, Northeast Health Wangaratta chief executive Tim Griffiths confirmed he had accepted a role with NSW Health after less than a year in the service's top job.

"Among her many achievements, the development of the recently launched strategic plan 2020-25 and her work on securing successful funding for renovations at Morrie Evans Wing are stand-outs," Benalla Health board chairman Dennis O'Brien said.

"The 2017 Premier of Victoria Medium Health Service of the Year award was another of her many contributions and testament to her work.

"Janine was a compassionate and respected leader, who led the organisation admirably during the many challenges of the COVID-19 outbreak, and who won the admiration of staff and board for her dedication to Benalla Health.

Ms Holland began working at the health service 12 years ago as the director of clinical services before being appointed chief executive.

She had been on extended leave, which was due to finish next month,and her resignation takes effect in July.

"We wish her all the very best in her future endeavours and know the community will be saddened to hear she is leaving the organisation," Dr O'Brien said.

During her period of extended leave Andrew Nitschke has been acting chief executive and he will continue in the role until a permanent replacement is appointed.

Mr Nitschke paid tribute to Ms Holland following her resignation.

"During her time here at Benalla Health, she has formed some wonderful and strong relationships in her work with the community, which have had a positive impact on the organisation and our future going forward," he said.

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