Albury Wodonga Health's vaccination hub in Wodonga could deliver 500 jabs in one day, pending supplies.
But initially, the health service's phase 1a operations will move to the hub in the former Coles building from Albury base hospital.
So far, 1000 priority health and aged care staff have been vaccinated with second jabs yet to be delivered.
Albury Wodonga Health chief operating officer Emma Poland expected the hub to start in "early April".
"It's looking good and we are almost ready to go with building inspections to happen tomorrow," she said.
"Once that's confirmed, we should have a start date.
"Initially it will be for that phase 1a for those priority workers, and that is by invitation and appointment only - they will be contacted if they're eligible.
"We've just delivered over 1000 vaccines to that first group, 1a, but there's still a number of weeks to go in terms of being able to deliver at least that first jab.
"I know for residential aged care facilities, we're working to a date of mid-April to try and have all of those people who haven't received their first vaccine (be vaccinated).
"We've commenced that outreach service to them."
People will enter via Hovell Street and register with administration staff before being seated in a waiting area.
They will then progress to one of six hubs; each hub has two nurses attached to it and six vaccination stations.
After being vaccinated, people will progress to a post-vaccination waiting area and be monitored for 30 minutes.
There are also two consulting rooms and two treatment rooms, and a pharmacy where the vaccine volume required each day will be stored and drawn up.
AWH has decided to keep its minus-70 degree freezer for the Pfizer jabs at Wodonga hospital.
The Pfizer and AstraZeneca vaccines will be transported from storage to the vaccine hub daily, as there is better security - including for power supplies - at AWH.
Ms Poland said the treatment rooms were in case of any adverse reactions, which have occurred for "a very small number" of people vaccinated by AWH through phase 1a.
"We will have a medical officer on site at all times and we will also have a system and process in terms of how to respond to that quickly and safely," she said.
"It's no different from a side effect of what you might see in terms of any reaction to any other vaccine - it's not unexpected."
Recipients do not get to choose which vaccine they receive, due to varying availability of supply, but will know whether they got the Pfizer or AstraZeneca jab.
As AWH delivers phase 1a, about 12 medical clinics around Wodonga have begun phase 1b: vaccinating elderly residents, Aboriginal and Torres Strait Islander adults 55 and over and people with medical conditions.
Most of the general public will be vaccinated later in the year under phase 2.
While GPs are expected to be a major distribution method for vaccinations, AWH is hopeful of its role.
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"The phase 1b has started to roll-out through our primary health care network, including our GPs," Ms Poland said.
"In terms of the role of this facility, that's still to come."
AWH has a 12-month lease for the former Coles building and is not occupying about one-third of the space - that is expected to be used by owners Chemist Warehouse.
Upgrades to the building have included fire systems and lighting.
Once AWH staff were able to access the building, they established the removable infrastructure and 36 vaccination points over a two-week period.