Over 1000 people are expected to hit the track for Nail Can Hill Run's return on Sunday.
Race director Stephen Wood said it was a relief for organisers to be able to get the race up and running once again.
"It's a really terrific feeling to be able to say 'we're back, the event is back," Mr Wood said.
Proceeds from this year's event will be going to the planned beneficiary of the 2020 event, Albury-Wodonga Border Rescue.
"We have the hope that we can provide them with a rescue boat that we had planned to do last year.
"We're looking to raise towards $50,000, which is normally what the event does return back to our community."
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Mr Wood said the abandonment of last year's run had been devastating.
"This event has been in the community for 44 years and to not be able to have it last year was awful and it was something that I felt the community did miss," he said.
The run's return hasn't been without its difficulties however, with uncertainty around the COVID-19 situation creating some headaches for organisers.
"We've had to work through a process and have a bit of a balancing act in saying 'can we get it done or can we not' and then of course going through all the necessary compliance," Mr Wood said.
"We were to some degree held back on promoting the event as early as we normally would, but we got to the point where the clear indications were that the COVID environment was opening up a little bit."
There are no restrictions on numbers for the race as it is an outdoor event, but COVID marshals will be onsite and social distancing is expected where possible. Entries are still being taken.