Sarkon Medical practice will run the clinic from the old ANZ building in Lavington Square.

It comes as the Border is on high alert after positive COVID-19 cases stopped in the Riverina, including at a Jindera service station.

The Murrumbidgee Local Health District said it can't assume there are no cases in the community.

Albury-Wodonga residents can currently be vaccinated at the Wodonga High Street hub or at participating GP practices.

Sarkon Owner Niranjan Sarjapuram said the clinic in time would administer Pfizer and AstraZeneca vaccines to people from both sides of the border.

"We are hoping to start from the end of this month, with a target date of the 26th of July," Mr Sarjapuram said.

"We will have five or six rooms, with four or five providers."

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Mr Sarjapuram said he expected the clinic to vaccinate 150 people in the first week.

"By the second week we are hoping to increase to 200, then by the third week 250 and by four weeks we'll be at 300 per day," he said.

"So at this stage we think 300 should be our target, but if we get more supply from the government we are more than happy to increase our numbers.

"Once the diary is up and running, it'll go up for online booking."

Mr Sarjapuram said walk-ins would also be accepted.

He said the clinic would operate for about two to three months at this stage and that the government had allocated about 500 to 600 Pfizer vaccines per week.

"Here's a set up by the private player, which the government could not do," he said.

"In the first two weeks we'll probably be having short days.

"Then we are going to increase once we get more supplies after July 31.

"We'll be doubling the doses around that stage and we'll also reach out to the local member of parliament to help us to get more doses for our clinic, so we can do more."

Mr Sarjapuram said it would be challenging to get enough medical staff to run the centre, especially with border restrictions limiting people coming from interstate.

"I'm trying to get the medical professionals extra across the border," he said.

"But we're using our local sources, we're reaching out to our network doctors within the Albury-Wodonga area in the other practices to come and help."

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Mr Sarjapuram said the clinic was also looking to volunteers to help run the service smoothly.

"We just need them to manage the traffic, the crowd coming in," he said.

"And the elderly people to help them fill out the consent forms, getting their details correct, checking, that sort of pre-registration help.

"We will help them to do it so they know everything."

He said if only a few staff could be recruited then the clinic would still run, but there would be a lower vaccination rate per day.

"I'm quite happy that we could be part of this initiative, but my staff are a bit apprehensive," he said.

"I keep telling them nothing is impossible, and yes, we can achieve it, even if things are hard work."

Mr Sarjapuram said he had been working 16 to 18 hour days to organise everything for the centre before the clinic location was finalised.

"I started [looking] a week ago once there was a new outbreak in Sydney and started realising we had more phone calls and more demand for the vaccines," he said.

"There were no other clinics coming forward so then I thought let's give a helping hand.

"Why don't we do it?

"Although we are small, let's work a little bit more, we'll pull out everyone to do this and just help the community."

The clinic can accessed from the Lavington Square complex carpark.

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