A Tasmanian man in his 40s has died after receiving a first dose of the AstraZeneca vaccine.
The death was confirmed in the latest COVID-19 vaccine weekly safety report from the Therapeutic Goods Administration on Thursday.
The man is a confirmed case of thrombosis with thrombocytopenia syndrome or TTS - the rare blood clotting disorder that has been linked to the AstraZeneca vaccine.
Health Minister Jeremy Rockliff said while the man was a confirmed case of TTS, the determination of cause of death was now a matter for the coroner.
"On behalf of the Tasmanian government, and personally, I extend my deepest sympathies to the man's family, his friends and his loved ones," he said.
"I can confirm the man died last weekend in hospital, where he had been receiving treatment.
"His family have asked for privacy on this matter, and our deepest respect for them, it is not appropriate to provide information that may identify the man."
State Health Commander Kathrin Morgan-Wicks said the man received his vaccination in a state-run clinic.
"As a result of this event, the Tasmanian Department of Health convened an expert alert advisory panel to review the case and report in detail to the TGA," she said.
"These are outlined in the TGA safety report."
A 48-year-old Victorian woman confirmed with TTS was also confirmed to have died in the past week.
Since the beginning of the vaccine rollout, more than 10.1 million doses of COVID-19 vaccines have been given.
The TGA has received and reviewed 399 reports of deaths in people who have recently been vaccinated and found six that were linked to immunisation.
These deaths were all related to the first dose of the AstraZeneca vaccine - five were TTS cases and one was a case of immune thrombocytopenia.
When asked on the two deaths today, the Prime Minister Scott Morrison said while there were risks associated with any vaccine, people were encouraged to make their own decisions.
"We are all responsible for our own health," Mr Morrison said.
"There has been the opportunity for people to visit a GP, the government provided that and funded it."