The male driver, who is yet to be formally identified, died at the scene in the crash which occurred on Wangaratta-Whitfield Road just before 10.30pm.

It's believed the vehicle crossed the north traffic lane and left the carriageway onto the grass verge before hitting a tree.

No passengers were in the vehicle and the exact cause of the crash is under investigation.

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Anyone with information that could assist investigators is urged to contact Crime Stoppers on 1800 333 000 or submit a report online.

It takes the total number of deaths on Victorian roads this year to 167, which has already surpassed last year's total of 153.

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