Albury-Wodonga has recorded six new cases on Wednesday, but isolation requirements for fully vaccinated COVID-positive individuals have changed.
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The Murrumbidgee Local Health District said NSW residents who'd received two doses of the vaccine could be released from isolation if they had no symptoms after 10 days.
Director of public health Tracy Oakman said if people were unvaccinated they must stay in isolation for 14 days.
"And when you're well at the end, then you can be released from isolation," she said.
"If people have ongoing symptoms though, they are asked to stay in isolation and they won't be medically released."
Ms Oakman said the Communicable Diseases Network Australia made the recommendation.
"They come off the back of understanding how infectious people were," she said.
"So people who were vaccinated who do get the infection towards the end, they're less infectious than people who are vaccinated, and that's why it's changed.
"They wouldn't be releasing anyone who they though was still infectious so by day 10 if you're asymptomatic, they don't believe you're infectious.
"People who continue to have symptoms, and particularly immuno-compromised people may have symptoms ... the evidence has shown that their body has not been able to eliminate the virus and so potentially they can be still infectious."
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The change may be welcome to some, including newly diagnosed COVID patients north of the Border.
One new case of COVID was recorded in Wodonga, five in Albury and Federation, four in Wangaratta and Wagga.
In Yarrawonga, where there is a growing outbreak, nine new cases were recorded, bringing the total active cases to 86.
Albury Wodonga Health confirmed 133 active cases across its catchment, while Murrumbidgee Local Health District is managing care for 107 COVID-19 patients, including one in hospital and one in intensive care.
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