A Ringwood East man was in a critical condition at The Alfred Hospital last night and the woman was in Wangaratta hospital with minor injuries.

Emergency services helped the pair, both believed to be in their 50s, after their vehicle travelling south lost control just past the Winton rest area about 1pm.

It then rolled several times, before landing on its roof.

It is unknown who was driving.

The man was found with serious cuts to his head and was airlifted to Melbourne.

Benalla SES attended the scene, with early reports the two were trapped, but they had both managed to get out of the vehicle either by themselves or with the help of passers-by.

Winton and Benalla CFA crews provided fire protection with fuel leaking from the vehicle.

The south-bound lane of the Hume Highway between the Winton rest area and the Benalla-Winton Road remained closed until about 4pm.

Meanwhile, a man, 66, was in a serious but stable condition at Wagga Base Hospital last night after his motorcycle and a semi-trailer carrying cattle collided at 10.40am yesterday.

The incident happened on the Sturt Highway, 8.5 kilometres west of the Hume Highway.