A MAN has died and four people injured in a car rollover on the Hume Highway.

Emergency services were called to the southbound lanes of the highway at Mullengandra about 7.30am.

A front seat passenger, who is yet to be formally identified, died at the scene.

The vehicle had lost control, skidded sideways, flipped and hit the tree on a median strip.

SES volunteers were needed to free the 22-year-old driver, two 19-year-old passengers and a 20-year-old passenger.

The four male survivors were transported to Albury hospital and one was later flown to Canberra.

The driver was in a critical condition following the crash.

Detective Inspector Winston Woodward said the car appeared to have been travelling from Sydney to Melbourne.

"It's too early to say a cause in relation to the incident," he said.

"It's a sad day, it's a sad morning.

"But the SES, Rural Fire Service, NSW Ambulance and police have done a professional job in assisting these five young individuals.

"It's tragic that these incidents happen but they do happen.

"A report will be prepared for the coroner and the matter will be fully investigated."

The incident caused delays on the southbound lanes of the highway.

Detective Inspector Woodward said highway patrol officers from Albury and Holbrook would investigate the circumstances of the crash.

"There have been witnesses who pulled up after the accident and assisted the young males," he said.

"Highway patrol were quick on scene.

"Anybody who witnessed the incident today on the highway, could you come forward."

Detective Inspector Woodward said the incident was "very confronting for those who attend".

The silver Kia was extensively damaged in the collision.

Tyre marks could be seen leading off the roadside into the crash scene.

Detective Inspector Woodward said he felt for the victims.

"My heart goes out to the family of the person who is deceased," he said.

"All too often we see situations like this.

"It's a tragic incident which has unfortunately occurred.

"The emergency services are doing their best to assist."

He said it was positive that drivers passing the crash scene were following laws which require them to slow to 40km/h.

Any witnesses to the incident can contact police on (02) 6023 9299.

UPDATE: 

A man has died, and four people have been injured in a single-vehicle crash near Albury this morning.

Emergency services were called to the Hume Highway, at Mullengandra about 7.30am following reports a car had crashed into a tree and rolled.

The male front seat passenger died at the scene.

Three male passengers were trapped in the vehicle before being freed by emergency services.

Two of the passengers have been taken to hospital by ambulance, while a third will be airlifted.

The male driver was taken by ambulance to Albury Base Hospital in a critical condition.

The ages of all involved are not yet known.

Officers from Murray River Police District remain at the scene and have launched an investigation into the incident.

Traffic diversions are in place and motorists are urged to avoid the area and to check www.livetraffic.com for updates.

PREVIOUSLY: 

AN AIR ambulance has been called to Mullengandra following a car rollover on the Hume Highway.

Emergency services were called to the incident about 7.30am.

There were limited details but a NSW Police spokeswoman said multiple people were believed to be trapped.

The incident occurred about 10 kilometres south of Holbrook and is causing traffic to be diverted.

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