A man in his 70s driving a Subaru packed full of luggage has been taken to Albury Hospital after a two-car crash just south of Chiltern.

The driver, in the Subaru with Tasmanian plates, was travelling along the northbound lanes of the Hume Freeway when a silver Toyota Camry turning onto the freeway collided with his car.

The 84-year-old female driver of the Toyota was turning from Wenkes Road, Rutherglen Sergeant Brian Curran said.

"A vehicle has been waiting at the intersection here at Wenkes Road, has turned into oncoming traffic in the freeway, and the other vehicle has collided with them," he said.

"As a result, we've got an 84-year-old female who has been taken to Wangaratta Hospital to make sure she's okay, and the driver of the other vehicle has been taken to Albury Hospital.

"They're not serious injuries, as far as we're aware, so hopefully it stays that way."

Numerous SES and CFA were involved in clearing the scene.

"It's been a little bit tricky because one of the cars has finished up on top of the barrier, it's been removed," he said.

"Traffic was banked up back to Springhurst, and we've been able to divert the traffic through Chiltern.

"There will be an investigation and I would imagine there will be some charges down the track."

Paramedics are assessing three people after a crash on the Hume Freeway, near Chiltern Valley.

An ambulance Victoria spokeswoman said the exact injuries or the severity of injuries were not yet known.

Initial reports to emergency services said two cars had crashed on the freeway about 12pm.

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Wodonga and Wangaratta police are also responding.

Northbound traffic on the freeway has been affected.

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