A motorbike rider has been airlifted to hospital after a crash involving a car in Wangaratta.
Police were called to Chisholm Street, near the intersection of Reid Street, about 11am on Monday.
A man in his 40s was flown to the Royal Melbourne hospital with serious upper and lower body injuries.
Leading Senior Constable Colin Boyle said police were keen to speak to anyone who saw the black spraypainted motorbike around Wangaratta before the crash.
Call (02) 5723 0888.