Opening batsmen Cooper Garoni and Cam Evans set Yackandandah up for success at Baranduda on Saturday.
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The visitors chased down Baranduda's score of 120 in 28 overs to seal the deal.
Garoni made 70 runs for a third consecutive week, continuing to make him one of the most in from batsmen in the competition.
He also left with two wickets to his name.
Evans made 29 runs, while also taking three wickets for the day.
Yackandandah captain Bailey Glass said the pair were instrumental in the win.
"They helped set us up," Glass said.
"We were none for 60 after about 12 overs and just cruised home after that.
"Cam and Mick (Walker) bowled well at the start.
"It was a good all round performance."
The captain again praised the efforts of Garoni for a consecutive week
"He's in exceptional form which is good," he said.
"Hopefully he can continue this."
Lewis Randell was Baranduda's leading runs scorer for the day with 29 before he was caught.
Captain Vince Moran made 24 runs in the clash, while Martyn Allwood and Kane Smillie took a wicket each.
In other district cricket games on the weekend, the reigning premiers were too strong for Eskdale at the Kiewa Cricket Ground.
Graeme Edwards set Kiewa up by taking three wickets, while Jacob Ozolins and Ashley Sutherland split 52 runs between them.
Jye Hodgkin topscored with 29 runs for Eskdale.
Dederang knocked off Bethanga at home by one run to finish on 146.
Andrew Creamer made 48 for the victors before he was run out, while Luke Deans aided Dederang with four wickets.
Jack Robinson had another solid week for Bethanga contributing 45 runs to the final tally.
Jarrod Scammell and Trent Sirl also contributed with the bat for the visitors.
Barnawartha-Chiltern defeated Mount Beauty by 13 runs with openers Findlay Lappin and Caleb Boxall leading the way.