Four people were taken to hospital following a crash at Londrigan, between Wangaratta and Eldorado, on Sunday morning.

A vehicle failed to give way at the Carraragarmungee Estate Road and Wangaratta-Eldorado Road intersection about 10.30am.

A driver pulled in front of the oncoming car, causing the crash, and causing both cars to be written off.

Drugs and alcohol were not involved and the driver at fault will receive a ticket for failing to give way.

Two men and two women were taken to Wangaratta hospital for observations.

The crash followed a similar incident on the Wodonga-Yackandandah Road at Baranduda about 30 minutes earlier.

Two cars collided near the intersection of Jamieson Drive.

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Four people, including a primary school aged boy, were assessed at the scene but nobody was injured.

Drivers also crashed near Mt Hotham in two separate incidents.

A 32-year-old man from Dinner Plain crashed 25 metres off the side of the Great Alpine Road about 3.30pm on Friday.

His vehicle was stopped by trees and he had to be pulled to safety.

A four-wheel-drive also crashed on the road after taking a bend too quickly about 10.15am on Saturday.

The vehicle, driven by a 19-year-old, slid into a dual cab ute.

Leading Senior Scott Baldock said both of the Alpine crashes involved people not driving to the conditions or paying enough attention.

"The message is to pay attention to your driving, don't get distracted," he said.

"Unfortunately, if you get distracted these things tend to happen."

A Rutherglen man, 54, also lost his licence after being caught drink driving at .09 in the town's main street about 1am on Sunday.

Officers in NSW and Victoria will finish their road safety operations at midnight on Monday.

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