Police said the man, 43, was riding along Epping-Kilmore Road about 12.55pm.

"He lost control of his red Victory motorcycle and crashed," police said in a statement.

"The rider was taken to hospital with life-threatening injuries but later died."

Investigations into the circumstances of the fatal crash continue and anyone who witnessed the incident, has dashcam footage or any other information that could assist police can contact Crime Stoppers on 1800 333 000 or submit a confidential report at crimestoppersvic.com.au.

IN OTHER NEWS:

Our journalists work hard to provide local, up-to-date news to the community. This is how you can continue to access our trusted content: