Wangaratta is two wins clear in third spot after edging out Lavington in a four-goal thriller on Saturday.
The Pies have won the past two grand finals, but the Panthers snared a two-goal break at quarter-time before the visitors seized the initiative to claim a 45-41 win.
Amanda Umanski posted 39 goals to dominate her team's scoring, although it was a cracking clash against interleague defender Sarah Meredith, who was the Panthers' best.
Maddy Plunkett chipped in with 32 goals for the home team, while centre Angela Demamiel also played well.
Defenders Kate Dean and Hannah Grady were excellent for the Pies.
The win, and Myrtleford's seven-goal loss to Corowa-Rutherglen, means Wangaratta leads the fourth-placed Saints by eight points with eight rounds left.
Myrtleford's slow start proved the difference against the Roos.
The away team led 12-5 at quarter-time before both teams shot 29 apiece to round out a 41-34 result.
The league's runaway leading scorer Grace Senior fired 22 goals, while Zoe McLeish was perfection with 16 from 16 attempts.
Centre Ella Kingston and goal keeper Emily Laracy were the Roos' best, while Tara Breen and Rebecca Piazza were the pick for the Saints from the same positions respectively.
Wangaratta Rovers grabbed their third win to move within two of fifth-placed Lavington.
The teams went to three-quarter time at 30-all, but a knee injury to Rovers' wing attack Katey Pryor forced a break.
"When we had that injury time it could have gone either way, but I thought the girls really stood up in that last quarter," Rovers' coach Noel Hatton explained.
"We brought some girls up from B grade in Jeynelle Mills in defence and Charlotte Proft went into goal attack, they held their nerve and I thought the result was fantastic."
The home team posted a 47-41 win, with Kelsie Wilson featuring with 31 goals, along with centre Ashlee Martin.
Kylie Murphy snared 21 for the visitors, with wing attack Ella Vandermeer joining her in the best.
Wodonga Raiders and Albury played out the year's first draw, 28-all.
Taylor Donelan excelled for the home outfit with 21 goals, while Albury's Sarah Moore shot 19, with Kate Yensch and Emily Rodd starring for the visitors.
And Yarrawonga toppled North Albury, 54-38.
Sarah Senini and Bridget Cassar bagged 26 goals apiece, while Natalie Heagney fired 32 for the visitors.
IN OTHER NEWS:
Kylie Leslie (Pigeons) and Molly Goldsworthy (North) were the pick of the players.
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