"The woman's only passenger, an 11-year-old boy, was trapped for a short time before being freed by Fire and Rescue NSW," police said in a statement on Tuesday.

"He was treated by NSW Ambulance paramedics for arm injuries before being flown to hospital where he's believed to be in a stable condition."

Riverina Police District officers had found a northbound Toyota Corolla and a southbound prime mover collided head-on in the northbound lanes, before the truck travelled over an embankment.

The male driver of the heavy vehicle, also aged 48, was taken to hospital to be checked and undergo mandatory testing.

Snowy Mountains Highway remained closed early Tuesday morning between Miles Franklin Drive at Talbingo and Link Road, Adaminaby/Kosciuszko National Park.

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MONDAY: One woman has died and two men were injured following a collision involving a car and a truck on the Snowy Mountains Highway about 20km east of Talbingo.

A NSW Police spokesperson has confirmed to The Daily Advertiser that the female driver of the sedan died on the scene and is yet to be formally identified.

A young male passenger was trapped for a short time before being freed by Fire and Rescue NSW, the spokesperson said.

The male passenger was treated by paramedics before being taken to hospital for further treatment.

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The male truck driver was also taken to hospital for treatment and mandatory testing.

Officers attached to Riverina Police District established a crime scene which will be examined by specialist police from the crash investigation unit.

The Snowy Mountains Highway is closed between Tumut and Cooma, and motorists are urged to avoid the area.

Police are appealing for anyone with information or dashcam footage to come forward and contact Crime Stoppers on 1800 333 000.

EARLIER:

One person is reported to be trapped after a serious incident on the Snowy Mountains Highway near Old Mountain Road Walk, Talbingo.

Emergency services were called to the incident 20km south of Talbingo at 2.45pm on Monday with reports of a crash involving a truck and a car.

Five paramedic crews are attending the scene with a NSW Ambulance helicopter said to be on the way.

According to a NSW Ambulance spokesperson, the truck driver is being treated for "minor injuries" at the scene.

Snowy Mountains Highway is closed both ways between Miles Franklin Drive, Talbingo and Link Road, Adaminaby/Kosciuszko National Park.

Motorists are advised to avoid the area and delay their trips as there is no suitable diversion available.